ea0035p62 | Adrenal Medulla | ECE2014
Martino Maria Cristina De
, Feelders Richard A.
, Dogan Fadime
, Koetsveld Peter M. van
, Krijger Ronald R. De
, Janssen Joseph A M J L
, Sprij-Mooij Diana
, Lamberts Steven W. J.
, Herder Wouter W de
, Colao Annamaria
, Pivonello Rosario
, Hofland Leo J
The mTOR and IGF pathways have been suggested to play a role in the pathogenesis of pheochromocytomas (PCC). mTOR inhibitors, as sirolimus (S) and everolimus (E), as well as IGF1R antagonists could be a potential novel treatment for malignant PPC.The aim of this study was to evaluate the expression of the main components of the IGF/mTOR pathway in human PCC and to investigate the effects of the mTOR inhibitors S and E and of the IGF1R/insulin receptor (I...